Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks
نویسندگان
چکیده
منابع مشابه
Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks.
Caspase 3 is required for the differentiation of a wide variety of cell types, yet it remains unclear how this apoptotic protein could promote such a cell-fate decision. Caspase signals often result in the activation of the specific nuclease caspase-activated DNase (CAD), suggesting that cell differentiation may be dependent on a CAD-mediated modification in chromatin structure. In this study, ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0913089107